TRANSLATIONAL PHYSIOLOGY Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis
نویسندگان
چکیده
Fina Lovren, Yi Pan,* Adrian Quan,* Hwee Teoh, Guilin Wang, Praphulla C. Shukla, Kevin S. Levitt, Gavin Y. Oudit, Mohammed Al-Omran, Duncan J. Stewart, Arthur S. Slutsky, Mark D. Peterson, Peter H. Backx, Josef M. Penninger, and Subodh Verma Division of Cardiac Surgery and Cardiology, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada; Departments of Surgery, Medicine and Physiology, Division of Cardiology, University Health Network, R. Samuel McLaughlin Centre for Molecular and Regenerative Medicine, Heart and Stroke Richard Lewar Centre of Excellence, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada; Division of Vascular Surgery, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia; and IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria
منابع مشابه
Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.
The endothelium plays a central role in the maintenance of vascular homeostasis. One of the main effectors of endothelial dysfunction is ANG II, and pharmacological approaches to limit ANG II bioactivity remain the cornerstone of cardiovascular therapeutics. Angiotensin converting enzyme-2 (ACE2) has been identified as a critical negative modulator of ANG II bioactivity, counterbalancing the ef...
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